Unexpected hope for a multiple myeloma patient

Multiple myeloma (MM) is a plasma cell neoplasm, characterized by periods of remission and relapses. The emergence of novel therapies, with multiple mechanisms of action and fewer adverse reactions, brings more and better options and also a higher survival rate. However, MM is still an incurable disease, and patients eventually become refractory to an extensive range of therapies. We present the case of a patient diagnosed with MM standard risk, who was at first refractory to multiple treatment regimens, and then had an unexpected and stable complete response to a newer drug of the same class

Findings of the VarDial Evaluation Campaign 2022

This report presents the results of the shared tasks organized as part of the VarDial Evaluation Campaign 2022. The campaign is part of the ninth workshop on Natural Language Processing (NLP) for Similar Languages, Varieties and Dialects (VarDial), co-located with COLING 2022. Three separate shared tasks were included this year: Identification of Languages and Dialects of Italy (ITDI), French Cross-Domain Dialect Identification (FDI), and Dialectal Extractive Question Answering (DialQA). All three tasks were organized for the first time this year

Findings of the VarDial Evaluation Campaign 2022

This report presents the results of the shared tasks organized as part of the VarDial Evaluation Campaign 2022. The campaign is part of the ninth workshop on Natural Language Processing (NLP) for Similar Languages, Varieties and Dialects (VarDial), co-located with COLING 2022. Three separate shared tasks were included this year: Identification of Languages and Dialects of Italy (ITDI), French Cross-Domain Dialect Identification (FDI), and Dialectal Extractive Question Answering (DialQA). All three tasks were organized for the first time this year.Non peer reviewe

Main challenges of residential areas

The present article is a position paper aiming to initiate a professional debate related to the aspects related to the urban dysfunctions leading to the wear of the residential areas. The paper proposes a definition of the wear process, identify the main causes leading to its occurrence and propose a number of solutions to neutralise the dysfunctions. The three wearing phases of residential areas components are emphasized, exploring their lifecycle. In order to perform the study of urban wear, the status of the residential areas components can be established and monitored, and also the variables of the function that can mathematically model the specific wear process may be considered. The paper is considered a first step for the model adjustment, to be tested and validated in the following steps. Based on the mathematical method and model, there can be created, in a potential future research, the possibility of determining the precarity degree for residential areas/neighbourhoods and cities, by minimising the subjective component of the analyses preceding the decision for renovation or regeneration

3D Geo-information in urban climate studies

3D geo-information is essential for urban climate studies. It is obvious that both natural environment and built-up environment play the fundamental role in defining the climatic conditions for urban areas, which affect the quality of human life and human comfort. The paper presents the main categories of 3D geo-information used in urban climate studies and roles in creating and operating the numerical models specially designed to simulate urban planning scenarios and improvement of the urban climate situation. 3D geo-information is essential for urban climate studies. It is obvious that both natural environment and built-up environment playthe fundamental role in defining the climatic conditions for urban areas, which affect the quality of human life and human comfort.The paper presents the main categories of 3D geo-information used in urban climate studies and roles in creating and operating thenumerical models specially designed to simulate urban planning scenarios and improvement of the urban climate situation

Selective waste collection optimization in Romania and its impact to urban climate

According to European Directives, transposed in national legislation, the Member States should organize separate collection systems at least for paper, metal, plastic, and glass until 2015. In Romania, since 2011 only 12% of municipal collected waste was recovered, the rest being stored in landfills, although storage is considered the last option in the waste hierarchy. At the same time there was selectively collected only 4% of the municipal waste. Surveys have shown that the Romanian people do not have selective collection bins close to their residencies. The article aims to analyze the current situation in Romania in the field of waste collection and management and to make a proposal for selective collection containers layout, using geographic information systems tools, for a case study in Romania. Route optimization is used based on remote sensing technologies and network analyst protocols. Optimizing selective collection system the greenhouse gases, particles and dust emissions can be reduced